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12th Annual Conference on Stem Cell and Gene Therapy, will be organized around the theme “New Trends and Technologies in Stem Cell Research”

StemGen 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in StemGen 2019

Submit your abstract to any of the mentioned tracks.

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Stem cells are those which are undifferentiated at the biological level and have an ability to divide to produce many stem cells. They can be found in multicellular living organisms. In mammals, there are two broad types of stem cells: Embryonic and Adult stem cells. Embryonic Stem cells are also known as pluripotent stem cells isolated from the inner cell mass of blastocysts, where Adult stem cells are found in various tissues. The main function of stem cells and progenitor cells is to act as a repair system for the body, replenishing adult tissue. Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. Epigenetic modifications are reversible modifications on a cell’s DNA that affect gene expression without altering the sequence of DNA. Epigenetic modifications play an important role in gene expression and regulation, and are involved in numerous cellular processes such as in differentiation or development and tumorigenesis. Epigenetics is a study on a global level and through the adaptation of genomic high-throughput assays

 

  • Track 1-1Induced pluripotent stem cells
  • Track 1-2Mesenchymal stem cells
  • Track 1-3Cancer stem cells
  • Track 1-4Bone marrow stem cells
  • Track 1-5Hematopoietic stem cells
  • Track 1-6Embryonic stem cells
  • Track 1-7Adult stem cells
  • Track 1-8Stem cell therapy and applications
  • Track 1-9Human cloning
  • Track 1-10Nuclear reprogramming

The anatomical region where stem cells are found in a shallow recess is referred to a stem-cell niche. It refers to a microenvironment with reference to the in vivo or in vitro stem cells; they even interact with stem cells to regulate cell fate. Various niche factors act on embryonic stem cells to induce their proliferation or differentiation for the development of the fetus and in altering the gene expression during the embryonic development. In the human body, stem cells maintain the adult stem cells in a dormancy state, but during the tissue injury it actively signals to stem cells to promote either self-renewal or differentiation to form a new tissue

  • Track 2-1GSC niche in drosophila ovaries
  • Track 2-2Molecular mechanism of GSC
  • Track 2-3Vertebrate adult stem cell niche
  • Track 2-4Extracellular matrix mimicking strategies
  • Track 2-5Atrial cardiac stem cells niche

Bioprocessing is a technology used for transferring the current laboratory-based practice of stem cell tissue culture to the clinical research as therapeutics necessitates for the application of engineering principles and practices to achieve control, automation, safety, validation and reproducibility of the process and the product. Biobanks are the type of biorepositories which collects, processes, stores and distributes biospecimens to support future scientific investigation. This plays an important role in helping the researchers providing the background knowledge of the subject. In order to preserve tissues and cells collected for scientific purposes, a number of important techniques and protocols must be utilized. Moreover, the predominant methods in widespread use, cryopreservation and hypothermic storage, have shortcomings in application and assessment.

 

  • Track 3-1Cryopreservation methods
  • Track 3-2Fertility preservation
  • Track 3-3Vitiligo biobank
  • Track 3-4Human cancer bio-bank
  • Track 3-5Hypothermic storage

Scaffolds are of great importance in clinical medicine. It is an upcoming field, and usually associated with conditions involving organ disease or failure. It is used to rebuild organs and return normal function. Stem cells along with regenerative medicine can be used to create ‘Scaffolds’ in the human body. Tissue regeneration is a branch of Regenerative medicine which deals with the study of regrowth or repair of the damaged or lost tissues in response to the injury. Non-injured tissues by default have expanded cells in the formation over time, but the new cells formed in response to the injury replaces the expanded cells in closing up the wounded site leaving a scar mark on the skin. For example, an injured cell is regenerated in 4-5 weeks, whereas a non-injured cell regenerates in just 3-4 days.

 

  • Track 4-1Scaffold designs
  • Track 4-2Fabrication of scaffolds
  • Track 4-3D scaffolds and models
  • Track 4-4Surface ligands and molecular architecture
  • Track 4-5Porous scaffolds
  • Track 4-6Biodegradable nano-fiber scaffolds

The process of “replacing tissues or organs, engineering or regenerating human cells to restore or establish normal function” is generally termed as Regenerative medicine. Regenerative medicine is a branch of Translational Research in the areas of tissue engineering and molecular biology. Regenerative medicine stimulates the body’s own repair mechanisms to engineer the damaged tissues and organs.

  • Track 5-1Cellular engineering
  • Track 5-2Nuclear reprogramming
  • Track 5-3Progenitor cell injection
  • Track 5-4In-vitro grown organ transplantation
  • Track 5-5Genetic engineering
  • Track 5-6Functional restoration

3D printing is a 3-dimentional printing machine which gives the information of a 2D image in the form of 3D object. The layer of materials to form a 3D object is controlled by the computer by providing geometry of the object. 3D Bioprinting aids Tissue Engineering by providing an in depth information of the image and structure analysis of the image, which helps in solving the critical problems. Biofabrication is referred to the production of artificial tissues or organs to address health challenges in medicine. It often uses the principle of 3D Bioprinting to form cells, gels and fibers into an organ.

 

  • Track 6-1Bioprinting using microfluidics
  • Track 6-2Bioinks
  • Track 6-3Engineered Tissue
  • Track 6-43D printing technologies
  • Track 6-5Innovative development in 3D-bioprinting
  • Track 6-6Intelligent bio materials

Stem cell therapy is the use of stem cells to treat/prevent a disease. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease. The most well-established and widely used stem cell treatment is the transplantation of blood stem cells to treat diseases and conditions of the blood and immune system or to restore the blood system after treatments for specific cancers.

 

  • Track 7-1Autoimmune disease stem cell treatment
  • Track 7-2Blood and skin diseases
  • Track 7-3Organ Cancer: gastric cancer, breast, oral, head and neck cancer
  • Track 7-4Lymphoma
  • Track 7-5Alzheimers
  • Track 7-6Periodontal diseases and stem cells

Stem cell transplantation also referred to as bone marrow transplant, in which unhealthy blood-forming cells replace with healthy cells. A procedure in which a patient receives healthy stem cells to replace their own cells destroyed by disease or high doses of anticancer drugs or by the radiation that are given as part of the procedure. The healthy stem cells may come from the bone marrow of the patient, blood, from a donor or from the umbilical cord blood. A stem cell transplant may be autologous, allogeneic or syngeneic. Many researchers are working to improve stem cell transplantation procedures to make it an option for patients.

 

  • Track 8-1Autologous stem-cell transplantation
  • Track 8-2Syngeneic stem cell transplantation
  • Track 8-3Peripheral stem cell transplantation
  • Track 8-4Stem cell transplantation for articular cartilage repair
  • Track 8-5Allotransplantation
  • Track 8-6Soft tissue cell replacements
  • Track 8-7Stem Leydig cells: effective treatment for testosterone
  • Track 8-8Transplantation of bone marrow stem cell

Self-reestablishment and multiplication of foundational microorganism populaces is controlled, to some degree, by affectation of apoptosis. Apoptosis of stem cells is a dynamic process which changes accordingly to the response to environmental conditions. The number of stem cells are always balanced between the lost through differentiation and to the gained through proliferation. Self-renewal and multiplication is controlled to some degree by the affectation of apoptosis. Because of natural conditions apoptosis of immature microorganisms is accepted to be dynamic.

 

 

  • Track 9-1Dysregulation of apoptosis
  • Track 9-2p53 Pathway and heat shock proteins (HSPs)
  • Track 9-3Inhibitors of apoptosis (IAPs) and regulators
  • Track 9-4Apoptosis transcription factors and regulators
  • Track 9-5Cancer stem cells and impaired apoptosis
  • Track 9-6Tocris small molecules for apoptosis research

It has been stated that stem cells have an ability to produce a large number of cells which in turn helps in forming the destroyed tissue or an organ. In contrast, stem cells can also be aided in repairing the damaged organs, in which the mechanism carries out in two different options: support mechanism and replace option. The support mechanism of the stem cell is regeneration or the regrowth of the tissue or organ cells avoiding detrimental fibrosis. The replace option of the stem cell is to transplant the stem cell.

 

  • Track 10-1Seeds of regeneration
  • Track 10-2Cell transplantation therapy
  • Track 10-3Stem cells to liver tissues
  • Track 10-4Stem cell exosomes
  • Track 10-5Hematopoietic stem cell homing
  • Track 10-6Mesenchymal stem cells: harnessing cell plasticity
Injury or sickness of individuals makes their cells to die or dysfunctional. Ageing is the demonstration of the internal depletion of stem cells. It shows that human beings could not without stem cells. For a diverse group of treatment purpose adult stem cells can be used. Adult Stem cell resides in-vivo in the form of self- renewing pools & helps in repairing/replacement of damaged tissues over the survival of the organism.

 

  • Track 11-1Telomeres and stem cell aging
  • Track 11-2Atrophy
  • Track 11-3Endothelial progenitor cells
Nanotechnology is the branch of technology that deals with small things that are less 100 nm in size. Here, to tackle the position of stem cells for some bio therapeutic applications we need to work at the size scales of molecules & processes that govern stem cells fate. Nanotechnology and Nano science offers immense benefits to humans with effective amalgamation of nanotechnology & stem cells.

 

  • Track 12-1Small molecule delivery
  • Track 12-2Gene delivery
  • Track 12-3Targeting tumours with nanoparticles
  • Track 12-4Combination therapies
  • Track 12-5Nano dimensional artificial antigen presenting cells (aAPCs)
Gene Therapy is used to treat inherited Muscular disorder, cardiovascular disorder, HIV, cancer etc. In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or as a way for the donor's immune system to provoke immunity against some types of cancer and blood-related diseases, such as leukaemia. Cellular Therapy is internationally recognized for its novel approaches in treating blood related disorders like leukaemia, lymphoma, myeloma, and other life-threatening diseases. The stem cell transplantation of hematopoietic stem cells (HSCT) in which the allogeneic hematopoietic stem cells are harvested from healthy donors of same species and autologous stem cell from the patient itself. Both therapies use high dosage cytotoxic medication in order to induce higher remission rates against malignant diseases. Autologous HSCT preferably used in relapsed malignant high-grade lymphoma and Allogeneic HSCT preferred for therapeutic effect against acute leukaemia with unfavourable prognosis in a high percentage of patients. The Recent developments based on the expansion of the donor pool for allogeneic stem cells in order to reduce dosage as well as chemotherapeutic toxicity of allogeneic transplantation with sustainable anti-leukaemia efficacy.

 

  • Track 13-1Orthopedic repair
  • Track 13-2Neurological disorder
  • Track 13-3Blindness vision impairment
  • Track 13-4Wound healing
  • Track 13-5Cancer
  • Track 13-6HIV
  • Track 13-7Cardiovascular disorder
Classical methods of gene therapy include transfection. It became inefficient and limited mainly due to delivery of gene into actively proliferating cell s in-vitro. Gene therapy utilizes the delivery of DNA into cells by means of vectors such as biological in-vitro or viral vectors and non-viral methods. The Several kinds of viruses vectors used in gene therapy are retrovirus, adeno-associated virus and herpes simplex virus. While other recombinant viral vector systems have been developed, retroviral vectorsremain the most popular vector system for gene therapy protocols and widest application due to their historical significance as the first vectors developed for efficient gene therapy application and the infancy of the field of gene therapy.

 

  • Track 14-1Vectors for gene therapy
  • Track 14-2Retroviral and other viral vector
  • Track 14-3Non -viral vectors in gene therapy
  • Track 14-4Calcium phosphate transfection
  • Track 14-5Electroporation
  • Track 14-6Transductional targeting
  • Track 14-7Fusion protein targeting
Genome editing technology deals with engineered nucleases and it is the emerging type of genetic engineering. it is the technology in which the  DNA is inserted, deleted or replaced in the genome. The emergence of highly versatile genome-editing technologies has provided investigators with the ability to rapidly and economically introduce sequence-specific modifications into the genomes of a broad spectrum of cell types and organisms. It also promotes various changes in sub cellular level genome editing itself also holds tremendous potential for treating the underlying various idiopathic genetic causes of certain diseases. The core technologies now most commonly used  techniques to facilitate genome editing are clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9),  transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs), and homing endonucleases or mega-nucleases.

 

Tissue engineering is the combinational usage of cells, engineering, materials methods, suitable biochemical and physicochemical factors in order to improve or replace the infected biological tissues. The field includes the development of materials, devices,  techniques to detect and  differentiate disease states ,the treatment response, aid tissue healing, precisely deliver treatments to tissues or cells, signal early changes in health status, and provide implantable bio artificial replacement organs for recover or establish of healthy tissue .Techniques developed here identify and detect biomarkers of disease sub-types, progression, and treatment response, from tissue imaging, gene testing and gene analysis, that aid the more rapid development of new treatments and guide their clinical applications in treating the disorder. It includes the usage of computational modelling, bioinformatics and quantitative pharmacology to integrate data from diverse experimental and clinical sources to discover new drugs and specific drug targets, as well as to design more efficient and informative preclinical, clinical safety and efficacy studies.

 

  • Track 16-1Biomarkers
  • Track 16-2Metabolic imaging technology
  • Track 16-3Computational modelling
  • Track 16-4Bioinformatics
  • Track 16-5Quantitative pharmacology
  • Track 16-6Gene therapy for bone engineering
Therapeutics is the branch of science dealing with the application of remedies of diseases. Moving on to the gene therapeutics it is medicine which we develop a remedy for a disease through the genetic material. Advanced gene therapeutics is a medicine we use the drugs to treat a disease by developing dosage forms to optimize drug action, underpin new formulations that target molecules spatially within the body, enhance the bioequivalence of poorly soluble drugs and biologics, and improve patient experience and compliance

 

Infectious diseases remain a leading cause of deaths globally. Scientific models are utilized to comprehend the transmission of infections. The applications incorporate deciding ideal control approaches against new or creating infections, such as swine flu, Ebola, HIV, Zika, malaria and tuberculosis. It can be used to predict the impact of vaccination strategies against common infections such as rubella and measles.  The process of research or discover of a medicine for a disease is generally called as drug discovery. In contrast, patient specific drug discovery is a process of inventing a drug by considering the pros and cons and the anatomical conditions of the patient. The general medicine is discovered on the basis of the active ingredient from traditional remedies or serendipitous discovery. It can also be referred as personalized medicine, which separates patients into different categories.

 

The world trade market for cell and gene based therapies is expected to greater than the $20 billion USD mark by 2025, with an annual growth rate of 21%. The main targets for cell based therapies are high impact disease areas with significant incurable needs, including cancer, heart disease, neurodegenerative diseases, musculoskeletal disorders and autoimmune diseases gene therapies should then not be rushed to market but companies should gather the required data about the impact of therapy in human community with the appropriate duration of follow-up to allow proper evaluation by payers.

 

Clinical trials on gene therapy products are often varying from the clinical trials design for other types of pharmaceutical products. The differences in trial design are necessitated by the distinctive features of these products. The clinical trials also reflect previous clinical experience and evidence of medicine. Early experiences with products indicate that some Gene Therapy products may pose substantial risks to subjects due to effect at cellular and genetic level. The design of early-phase clinical trials of Gene therapy products often involves the following consideration of clinical safety issues, preclinical issues, and chemistry, manufacturing and controls (CMC) issues that are encountered.