Stem Cell and Regenerative Medicine

Stem Cells and Disease Modelling

Human pluripotent stem cells (HPSCs) are useful model system for understanding the genetic basis of human cardiovascular diseases. HPSCs are often firmly genetically matched to patients with disease. Previously, only in unusual substance was it viable to review primary tissues like heart muscle and blood vessels obtained directly from living patients, and even in such circumstances, the quantity of tissue was limited. HPSCs produce a replacement approach that gives a unique opportunity to review human cells that are matched to the patients of interest. Because they will be propagated into very large numbers and differentiated into a spread of cell types that are relevant to cardiovascular diseases—including cardio myocytes, vascular endothelial and smooth muscle cells, and hepatocytes—HPSCs can in theory provide a limitless source of fabric with which to dissect the molecular support of the patient’s disease process within and beyond the circulatory system.